Angiography is the established imaging technique for coronary imaging. Angiography is routinely used during all coronary diagnostic and interventional procedures.

Cardialysis has broad experience in different types of quantitative and qualitative angiography analysis since its foundation in 1983. To date, the Angiographic Core Lab has been involved in over 110 trials.

Quantitative Coronary Analysis (QCA)

QCA is a technique that provides objective and reproducible measurements of coronary artery dimensions. QCA is particularly useful for assessing the vessel lumen size, (re) occurrence of a (re-)stenosis after coronary interventions, the evaluation of mechanical interventional devices (e.g. stents) and the long-term progression and regression of coronary atherosclerosis.

Bifurcation Analysis

Cardialysis has applied a new approach to bifurcation analysis. As an addition to the conventional QCA analysis, a coronary bifurcation can be analyzed as a single object, including the central bifurcation area together with the angulation of the bifurcation. The entire bifurcation segment can be divided in a 6-segment or into a 11-segment bifurcation model. 

Besides a 2D QCA application, our Core Lab is also applying 3D QCA. Out-of-plane magnification and foreshortening errors are minimized by calculating a true geometric shape in 3D space from two or more 2D x-ray projections. QCA 3D offers improved analysis of difficult lesions and segment anatomy.

Qualitative (Visual) Assessment

The Angiography Core Lab has extensive experience in qualitative assessment of angiograms. The visual assessment of an angiogram may involve the analysis of morphological parameters, the coronary anatomy, the filling of coronary arteries, the cardiac function, and the evaluation of the result of an intervention according to pre-set definitions.

Myocardial Blush Grade

Myocardial blush is a measure of myocardial reperfusion in patients with acute myocardial infarction. It is estimated visually or measured using the Quantitative Blush Evaluator (QuBE).

Syntax Score

The SYNTAX Score is an angiographic tool to grade the complexity of coronary artery disease by characterizing the entire coronary tree with respect to the number of lesions and their functional impact, location and complexity. The SYNTAX Score can also be used to compare the complexity of coronary artery disease in individual patients and entire patient cohorts. At the Cardialysis Core Lab, we also apply the newly developed multislice computed tomography (MSCT) SYNTAX Score.

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Angiography Left Ventricular Analysis

Left Ventricular analysis is the contour detection of the diastolic and systolic left ventricle. The difference between the diastolic and systolic state is expressed as the percentage of the ejection fraction of the left ventricle. Using software with automatic contour detection, the left ventriculograms are analyzed to assess global and regional left ventricular function, volume calculation and wall motion analysis during e.g. procedural and follow-up studies.

Transcatheter Aortic Valve Implantation

The Cardialysis Core Lab is fully geared to facilitate the industry in TAVI clinical trials. The Core Lab has gained experience in angiography analysis such as the assessment of aortic regurgitation, depth of implantation and frame fracture.

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